Skinoren Cream Singapore: Evidence-Based Treatment for Acne, Rosacea, and Pigmentation
- 莉奈 長崎
- Nov 15, 2024
- 9 min read
Updated: 3 days ago
What is Skinoren Cream?
Skinoren Cream is a prescription topical treatment containing 20% azelaic acid. It is a pharmaceutical-grade medication formulated to address multiple skin concerns through scientifically validated mechanisms. As a prescription-only medication, Skinoren requires medical consultation and a doctor's prescription before use.
Azelaic acid is a naturally occurring dicarboxylic acid that works through multiple pathways to improve skin conditions. The cream is manufactured to pharmaceutical standards and is registered with the Health Sciences Authority (HSA) in Singapore for specific therapeutic indications, ensuring quality and safety standards are met.
How Azelaic Acid Works
Azelaic acid functions through several scientifically validated mechanisms. Research has demonstrated that it possesses antibacterial properties that help reduce Cutibacterium acnes (formerly Propionibacterium acnes), the bacteria associated with acne development. The compound also exhibits keratolytic activity, meaning it helps normalize the keratinization process in hair follicles, preventing pore blockages that lead to comedone formation.
Additionally, azelaic acid has anti-inflammatory properties that help reduce skin inflammation and redness. Its ability to inhibit tyrosinase, an enzyme involved in melanin production, makes it useful in addressing hyperpigmentation concerns. These multiple mechanisms allow azelaic acid to address several skin conditions simultaneously.
What Conditions Does Skinoren Treat?
HSA-Approved Uses in Singapore
Skinoren Cream 20% is registered with the Health Sciences Authority (HSA) for two specific indications:
Acne Vulgaris
Approved for treatment of mild to moderate inflammatory acne
Approved for treatment of comedonal acne (blackheads and whiteheads)
Rosacea
Approved for management of papulopustular rosacea
Also known as inflammatory rosacea, characterized by redness and pimple-like bumps
Other Potential Uses
While some doctors may consider azelaic acid for conditions such as melasma or post-inflammatory hyperpigmentation (PIH), these applications fall outside the HSA-registered indications for Skinoren Cream in Singapore. Any use beyond the approved indications should be discussed with a qualified doctor who can assess individual suitability and provide appropriate medical guidance.
Skinoren for Acne: What the Research Shows
Clinical Evidence for Acne Treatment
Multiple randomized controlled trials have evaluated azelaic acid's effectiveness in treating acne vulgaris. Clinical research analyzing numerous controlled trials has found that azelaic acid demonstrated significant improvements in inflammatory lesion counts and overall acne severity compared to placebo treatment.
How Skinoren Helps Acne
For acne patients, azelaic acid addresses the condition through multiple pathways. It reduces the bacteria associated with acne breakouts, helps prevent pore clogging by normalizing skin cell turnover, decreases inflammation that causes redness and swelling, and may help fade dark spots left behind by previous breakouts.
Expected Timeline for Acne Improvement
Weeks 1-2: Possible initial mild irritation as skin adjusts
Weeks 4-6: Early improvements in breakouts may become noticeable
Weeks 8-12: More significant reduction in acne lesions typically observed
Beyond 12 weeks: Continued improvement with consistent use
Individual response varies, and some patients may see results sooner or later than these typical timeframes.
Skinoren for Rosacea: What the Research Shows
Clinical Evidence for Rosacea Treatment
For rosacea, the clinical evidence is particularly robust. Research studies including comprehensive meta-analyses have demonstrated that azelaic acid significantly improved redness severity, inflammatory lesion counts, and overall treatment success compared to placebo after 12 weeks of use. Clinical trials have also shown that azelaic acid demonstrated superior efficacy compared to metronidazole 0.75% for reducing redness severity and inflammatory lesion counts.
Network meta-analyses examining treatments for moderate-to-severe papulopustular rosacea have found that azelaic acid 20% yielded highly favorable results and was ranked among the most effective topical treatments for improving overall treatment outcomes in this patient population.
How Skinoren Helps Rosacea
For rosacea patients, azelaic acid's anti-inflammatory properties help reduce facial redness and inflammation, while its antibacterial effects may help control factors that trigger rosacea flare-ups. The treatment can help decrease the number of papules and pustules (bumps and pimples) characteristic of papulopustular rosacea.
Expected Timeline for Rosacea Improvement
Improvement in rosacea symptoms often occurs after 4-12 weeks of consistent use. Your doctor will determine the appropriate duration of treatment based on your individual response and condition severity.
Skinoren for Pigmentation: Important Considerations
Research on Pigmentation Effects
Studies have examined azelaic acid's effects on melasma and post-inflammatory hyperpigmentation, with research showing improvements in pigmentation severity through its tyrosinase-inhibiting properties.
Critical Note on Pigmentation Treatment
Pigmentation indications such as melasma and post-inflammatory hyperpigmentation are not part of the HSA-registered uses for Skinoren Cream in Singapore. If your primary concern is pigmentation, discuss this with your doctor to understand whether Skinoren is appropriate for your situation and what the evidence shows for off-label application.
How to Use Skinoren Cream
Application Instructions
Skinoren Cream should be used exactly as prescribed by your doctor. Your healthcare provider will give you specific instructions based on your condition. General application typically involves:
Thoroughly cleanse and dry the affected area before application
Apply a thin layer of cream to the affected areas twice daily (morning and evening)
Gently massage the cream into the skin until fully absorbed
Wash hands thoroughly before and after application
Avoid contact with eyes, mouth, and mucous membranes
Important Note on Dosing
The amount of cream and frequency of application should be determined by your prescribing doctor based on your specific condition, skin type, and response to treatment. Do not adjust the prescribed amount without consulting your doctor.
Treatment Duration
Treatment duration varies depending on the condition being treated and individual response. For acne, improvement may be noticed after approximately 4 weeks of consistent use, though optimal results typically require several months of regular application. Your doctor will determine the appropriate duration of treatment based on your individual response and condition severity.
What to Expect During Treatment with Skinoren
Initial Adjustment Period
During the first few weeks of treatment, some patients may experience mild skin irritation, including slight stinging, redness, or dryness at the application site. These effects are generally temporary and tend to diminish as the skin adjusts to the medication. If you experience significant discomfort, consult your doctor, who may recommend adjusting application frequency initially.
Managing Side Effects
If you experience irritation:
Continue use as directed unless symptoms are severe
Contact your doctor if irritation persists beyond 2 weeks
Do not increase application frequency without medical advice
Ensure you are using a gentle, non-irritating cleanser and moisturizer
Potential Side Effects
As with any prescription medication, Skinoren Cream may cause side effects in some users. Common local reactions include:
Side Effect Category | Specific Reactions | Frequency |
Skin irritation | Burning sensation, stinging (typically 1-2 minutes), itching, dryness | Common, especially initially |
Appearance changes | Temporary redness, mild scaling or peeling | Common, usually temporary |
Sensitivity reactions | Contact dermatitis, skin hypersensitivity | Less common |
Most side effects are mild and transient. However, if you experience severe or persistent reactions, discontinue use and consult your doctor promptly.
Who Should Not Use Skinoren Cream
Contraindications
Individuals with known hypersensitivity to azelaic acid or any excipients in the formulation
Those with acute skin conditions or broken skin in the treatment area
Special Populations
Pregnancy and Breastfeeding:
While azelaic acid has minimal systemic absorption (less than 4%), pregnant or breastfeeding women should consult their doctor before use. Current evidence has not shown harm to developing fetuses, but medical guidance is essential.
Pediatric Use:
Safety and efficacy in children under 12 years have not been established in clinical trials.
General Precautions
Avoid applying to broken, wounded, or severely irritated skin
Do not cover treated areas with occlusive dressings unless specifically instructed by your doctor
Use sun protection during treatment, as with any acne or pigmentation therapy
Inform your doctor of all medications and skincare products you are currently using
Using Skinoren with Other Skincare Products
Combining with Other Products
When using Skinoren Cream, consider the following regarding product combinations:
Azelaic acid can generally be used alongside gentle, non-irritating skincare products. However, combining it with other active ingredients requires caution. Using multiple exfoliating agents simultaneously (such as retinoids, alpha hydroxy acids, or benzoyl peroxide) may increase skin irritation risk.
If your doctor recommends combining Skinoren with other prescription treatments, they will provide specific guidance on application timing and sequencing to minimize irritation while maximizing benefits.
Professional Aesthetic Treatments
If you are undergoing or planning professional aesthetic treatments such as laser procedures, chemical peels, or other intensive treatments, inform your doctor. They can advise on appropriate timing and whether to temporarily discontinue Skinoren use before and after such procedures.
Skinoren vs Other Acne and Rosacea Options
Different topical treatments work through various mechanisms and have distinct characteristics. Understanding these differences can help you and your doctor choose the most appropriate treatment:
Treatment | Mechanism | Tolerability | Best For | Key Considerations |
Azelaic Acid (Skinoren) | Antibacterial, anti-inflammatory, keratolytic, tyrosinase inhibitor | Generally well-tolerated; mild initial irritation common | Acne with pigmentation concerns; rosacea; sensitive skin | Multiple mechanisms; may help with post-acne marks |
Retinoids | Normalize cell turnover, anti-inflammatory | Significant initial irritation possible | Moderate to severe acne; anti-aging | Highly effective but may be too irritating for rosacea |
Benzoyl Peroxide | Strong antibacterial | Can be drying; may bleach fabrics | Inflammatory acne | Fast-acting; watch for excessive dryness |
Metronidazole | Anti-inflammatory, antibacterial | Generally well-tolerated | Rosacea | Less effective than azelaic acid for rosacea per meta-analyses |
Evidence-Based Comparisons
Compared to Retinoids:
While retinoids are highly effective for acne, they may cause significant irritation, especially during initial use. Azelaic acid typically causes less irritation and may be better tolerated by those with sensitive skin or concurrent rosacea.
Compared to Benzoyl Peroxide:
Benzoyl peroxide has strong antibacterial effects but can be drying and may bleach clothing and fabrics. Azelaic acid offers antibacterial benefits with additional anti-inflammatory and pigmentation-improving properties without the bleaching effect.
Compared to Metronidazole (for Rosacea):
Clinical evidence suggests azelaic acid may be more effective than metronidazole for reducing erythema and inflammatory lesions in rosacea patients. Both are considered first-line topical treatments for papulopustular rosacea.
Your doctor can help determine which treatment or combination of treatments is most appropriate for your specific skin concerns and condition severity.
How to Get Skinoren in Singapore
Prescription Requirements
Skinoren Cream 20% is classified as a prescription-only medication in Singapore. To obtain Skinoren, you must:
Consult with a registered medical doctor
Receive a medical assessment to determine suitability
Obtain a valid prescription
Fill the prescription at a licensed pharmacy or medical clinic
What Happens During Your Consultation
During your consultation, your doctor will:
Assess your skin condition and medical history
Determine if Skinoren is appropriate for your specific concerns
Provide personalized instructions for use
Discuss potential side effects and precautions
Schedule follow-up appointments to monitor treatment progress
Cost Considerations
Skinoren Cream is a prescription medication. Costs may vary depending on the clinic and whether you have insurance coverage. Discuss pricing with your healthcare provider or clinic during your consultation.
Frequently Asked Questions
Can I use Skinoren for anti-aging or skin texture improvement?
Skinoren Cream is registered in Singapore specifically for acne vulgaris and rosacea treatment. While some research has explored azelaic acid's potential effects on photoaging and skin texture, these applications are not part of the approved indications. Any such use would be off-label and should be discussed with a qualified doctor.
How long should I continue using Skinoren?
Treatment duration depends on your specific condition, its severity, and your response to therapy. Your doctor will determine the appropriate duration. Clinical trials have typically evaluated continuous use up to 12 months, though individual treatment plans may vary.
Can I stop treatment once my skin clears?
Acne and rosacea are chronic conditions that may recur after treatment discontinuation. Your doctor will advise on maintenance strategies, which may include continued use at a reduced frequency or transitioning to other maintenance therapies.
What if I miss an application?
If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply extra cream to make up for a missed dose.
Can I use makeup over Skinoren Cream?
Yes, you can typically apply makeup after Skinoren Cream has been absorbed (usually after a few minutes). Use non-comedogenic cosmetic products when possible, especially when treating acne.
Is Skinoren suitable for all skin types?
Skinoren can be used on various skin types, but individual suitability must be determined by your doctor based on your specific skin condition, sensitivity, and medical history.
How is Skinoren different from over-the-counter azelaic acid products?
Skinoren contains 20% azelaic acid and is a prescription medication registered with HSA. Over-the-counter products typically contain lower concentrations (10% or less) and are not regulated as strictly. The higher concentration in Skinoren provides stronger therapeutic effects but requires medical supervision.
Storage and Handling
Store at room temperature (below 30°C)
Keep container tightly closed when not in use
Protect from light and moisture
Keep out of reach of children
Do not use after the expiration date
Do not transfer to other containers
When to Contact Your Doctor
Seek medical advice if you experience:
Severe or worsening skin irritation
Signs of allergic reaction (severe itching, swelling, difficulty breathing)
Unexpected skin changes or reactions
No improvement after 4-8 weeks of consistent use
Worsening of your condition during treatment
Conclusion
Skinoren Cream containing 20% azelaic acid is an evidence-based prescription treatment option for acne vulgaris and rosacea in Singapore, registered with the HSA for these specific indications. Clinical research supports its efficacy through multiple mechanisms, including antibacterial, anti-inflammatory, and keratolytic actions.
Treatment outcomes depend on consistent use as directed, appropriate patient selection, and ongoing medical supervision. While generally well-tolerated, Skinoren may cause initial mild irritation that typically resolves with continued use.
For optimal results and safety, Skinoren Cream should only be used under the guidance of a qualified doctor who can assess your individual suitability, provide personalized instructions, monitor your progress, and adjust treatment as needed.
Please see below for treatment details.
Note: This article is for educational purposes only and does not constitute medical advice. Individual treatment plans should be developed in consultation with qualified healthcare professionals. Treatment outcomes vary from person to person, and no guarantee of results is intended or implied. All professional treatments mentioned should be performed by licensed medical practitioners in Singapore, using HSA-approved products, devices, and techniques, as applicable.
