What is Plinest Polynucleotide? The Ultimate Guide to Skin Rejuvenation
- Yoneda Narumi
- Jul 30
- 17 min read
Updated: Aug 15
Explore Plinest, a leading polynucleotide biostimulator. Understand how this injectable treatment regenerates skin on a cellular level, boosts collagen, and offers a unique approach to anti-aging.
An Introduction to Plinest and Polynucleotide Technology
Plinest is at the forefront of a new wave of aesthetic treatments focused on true skin regeneration. Unlike treatments that simply mask imperfections, Plinest harnesses the power of polynucleotide technology to repair and rejuvenate the skin from within. This introductory chapter explores the science behind Plinest, its cellular mechanism, and its pharmaceutical origins.
What Exactly is Plinest
Plinest is an injectable, medical-grade biostimulator and biorevitaliser designed to improve overall skin health, quality, and appearance. Its primary active ingredient is highly purified polynucleotides (PN-HPT™), which are natural, DNA-derived molecules that stimulate the skin's own regenerative capabilities.
Instead of adding artificial volume like traditional dermal fillers, Plinest works on a cellular level to encourage the production of essential skin components like collagen and elastin, leading to firmer, healthier, and more radiant skin over time.
The Science of Polynucleotides PDRN for Skin
Polynucleotides are DNA-derived molecules used in Plinest formulation. In aesthetic medicine, these chains are derived from trout DNA, which is used due to its high compatibility with human cells and its excellent safety profile. The polynucleotides used in Plinest are carefully filtered, purified, and sterilized using a patented technology to ensure they are free of proteins and other immunogenic components.
While often discussed alongside Polydeoxyribonucleotide (PDRN), Plinest's Polynucleotides (PN) have distinct characteristics.
How Plinest Stimulates Your Skin on a Cellular Level
Plinest initiates a cascade of regenerative events once injected into the skin. Its multi-faceted approach addresses skin aging and damage through several key mechanisms:
Fibroblast Stimulation: Polynucleotides may interact with cellular receptors to stimulate fibroblast activity. This signals the fibroblasts to increase the production of new Type I collagen and elastin, which are crucial for skin structure, firmness, and elasticity.
Deep Hydration: The long polynucleotide chains have a strong hydrophilic (water-binding) capacity. They attract and retain water molecules within the skin's dermal layer, resulting in deep, lasting hydration and a visible improvement in skin plumpness and texture.
Antioxidant Protection: PNs act as potent free-radical scavengers. They neutralize damaging molecules generated by environmental aggressors like UV radiation and pollution, protecting skin cells from oxidative stress and slowing the aging process.
Enhanced Tissue Repair: By creating an ideal physiological environment, Plinest supports the natural wound-healing process. It promotes the formation of new blood vessels (angiogenesis), improving blood flow and nutrient supply to the skin, which is vital for cellular health and repair.
The Mastelli Pharmaceutical Origin
Plinest is developed and manufactured by Mastelli, an esteemed Italian pharmaceutical company with over 70 years of experience. Mastelli is a pioneer in the research and production of polynucleotide-based products, originally focusing on their application in general medicine for wound healing and tissue regeneration.
This deep pharmaceutical heritage ensures that Plinest is produced to the highest standards of safety and efficacy. The company developed and patented its exclusive HPT™ (Highly Purified Technology) manufacturing process. This technology guarantees the extraction of polynucleotides with controlled chain lengths while ensuring exceptional purity by removing all proteins and other components that could trigger an immune response. This commitment to scientific rigour and quality makes Plinest a trusted and reliable choice for aesthetic practitioners worldwide.
The Core Benefits of Plinest Treatments
Plinest is not just another injectable; it is a biostimulator that works to regenerate your skin from within. Its primary function is to trigger the body's natural healing and rejuvenation processes, leading to comprehensive improvements in skin quality. The treatment offers a multi-faceted approach, addressing several concerns simultaneously for healthier, more youthful-looking skin.
Boosting Collagen and Elastin Production
One of the most significant benefits of Plinest is its ability to act as a powerful biostimulant. The polynucleotides send signals to key skin cells called fibroblasts, awakening them and stimulating them to produce fresh collagen and elastin. These two proteins are the fundamental building blocks of youthful skin:
Collagen: Provides strength, structure, and firmness. As we age, collagen production declines, leading to skin laxity and sagging.
Elastin: Gives the skin its ability to stretch and bounce back. A loss of elastin results in skin that no longer appears taut.
By restoring the production of these essential proteins, Plinest effectively helps to rebuild the skin's "scaffolding," resulting in visibly firmer, thicker, and more resilient skin.
Deep Hydration and Improved Skin Texture
Polynucleotides have a strong hydrophilic (water-attracting) effect. When injected into the skin, they draw and hold onto water molecules, providing deep and lasting hydration from within the dermis. This is different from topical moisturisers that only work on the surface. This hydration may contribute to improvements in skin texture, making it feel smoother, softer, and more supple. Patients often notice a reduction in the appearance of enlarged pores and a more refined skin surface.
Reducing Fine Lines Wrinkles and Signs of Aging
The combined effect of renewed collagen, increased elastin, and deep hydration directly counteracts the visible signs of aging. Plinest is particularly effective at softening and reducing static wrinkles—the fine lines that are visible even when your face is at rest. It helps to plump the skin from beneath, smoothing out crepey texture and fine lines around the eyes, mouth, and on the neck, leading to a naturally refreshed and rejuvenated appearance.
Repairing Damaged Skin and Reducing Scars
Plinest's regenerative properties make it an excellent treatment for repairing damaged skin and improving the appearance of certain types of scars. Its ability to promote cell turnover and tissue regeneration helps to:
May contribute to improvement in skin texture irregularities, by rebuilding the underlying dermal structure.
May help improve overall skin condition and improve its overall health.
May be considered for improvement of skin texture in various areas on the body.
Enhancing Overall Skin Radiance and Health
Beyond targeting specific problems, Plinest enhances the overall health and vitality of your skin. The polynucleotides may have antioxidant properties that contribute to premature aging from sun exposure and pollution. This protective action, combined with improved microcirculation, delivers more oxygen and nutrients to the skin cells. This may result in a brighter, more even-toned complexion.
The Plinest Treatment Procedure From Start to Finish
Understanding the journey of a Plinest treatment can help you feel confident and prepared. From the initial discussion with your practitioner to the final results, the process is straightforward and designed for your comfort and safety. Here is a step-by-step guide to what you can expect.
The Initial Consultation and Skin Assessment
Your Plinest experience begins with a thorough consultation with a qualified aesthetic practitioner. This crucial first step ensures the treatment is tailored to your specific needs and goals. During this session, you will:
Discuss Your Concerns: You will have the opportunity to talk about your skin concerns, whether they are fine lines, volume loss, skin laxity, dullness, or acne scarring.
Undergo a Skin Analysis: The practitioner will perform a detailed assessment of your skin type, tone, and condition to confirm your suitability for Plinest and determine the optimal treatment approach.
Review Medical History: A comprehensive review of your medical history, including allergies, past cosmetic procedures, and current medications, is conducted to ensure your safety.
Receive a Personalised Treatment Plan: Based on the assessment, the practitioner will create a customised plan that outlines the recommended number of sessions, treatment areas, and expected outcomes.
Ask Questions: This is the perfect time to ask any questions you have about the procedure, potential side effects, downtime, and costs.
How to Prepare for Your Plinest Session
Proper preparation can help minimise the risk of side effects like bruising and ensure a smooth procedure. Your practitioner will provide specific instructions, but general guidelines include:
One Week Prior: Avoid blood-thinning supplements and medications such as aspirin, ibuprofen, Vitamin E, fish oil, and ginkgo biloba, after consulting with your doctor. This helps reduce the likelihood of bruising at the injection sites.
48 Hours Prior: Refrain from consuming alcohol, as it can dehydrate the skin and increase the risk of swelling and bruising.
Day of Treatment: Arrive at your appointment with a clean face, free of makeup, lotions, or other products. Staying well-hydrated by drinking plenty of water is also recommended.
What to Expect During the Injection Process
The Plinest injection procedure is quick and minimally invasive. The entire appointment is typically completed within 30 to 60 minutes, with the injection portion taking only about 15 to 30 minutes.
Cleansing: The target area (e.g., face, neck, or hands) will be thoroughly cleansed and disinfected to prevent infection.
Numbing: A topical anaesthetic cream is applied to the skin and left on for approximately 20-30 minutes to numb the area, ensuring the treatment is as comfortable as possible.
Injection: Once the skin is numb, the practitioner will use a very fine needle to administer the Plinest polynucleotide gel. The product is delivered through a series of precise micro-injections into the superficial dermis. This may feel like a series of tiny pricks, but it is generally well-tolerated.
Completion: After the injections are complete, the practitioner will gently clean the skin again. You may notice small, raised bumps or papules at the injection sites, which is a normal and expected part of the treatment.
Post-Treatment Care and Managing Downtime
Downtime after a Plinest treatment is minimal, with most patients resuming normal activities immediately. However, following proper aftercare instructions is vital for achieving the best results and ensuring a quick recovery. Small bumps from the injections typically resolve within 24-72 hours.
Are You a Good Candidate for Plinest
Plinest is a versatile biorevitalisation treatment, but it's essential to determine if it aligns with your specific skin goals and health profile. This treatment focuses on cellular regeneration, making it suitable for a wide range of individuals seeking to improve their skin's fundamental health and appearance. Understanding who benefits most and who should avoid the treatment is the first step toward achieving optimal results safely.
Skin Concerns Best Addressed by Plinest
Plinest's regenerative properties make it highly effective for a variety of common skin concerns, from the first signs of aging to textural irregularities. It works by stimulating your body's own repair mechanisms rather than simply filling or masking imperfections.
Ideal Age Groups and Skin Types
Plinest is not limited by skin type or a narrow age bracket, making it a broadly applicable treatment for skin health maintenance and repair.
Age Groups: While individuals aged 30 and older who are noticing signs of aging like fine lines, volume loss, and dullness are prime candidates, Plinest is also highly effective as a preventative measure. Younger adults in their late 20s can use it to "bio-bank" their skin's vitality, slowing the aging process and maintaining a youthful complexion.
Skin Types: Plinest is suitable for all skin types, including dry, oily, combination, and sensitive skin. Its ability to restore balance and reduce inflammation makes it particularly beneficial for those with sensitive or reactive skin who may not tolerate more aggressive treatments. It works to improve the skin's foundational health, regardless of its type.
Contraindications and Who Should Avoid Plinest
Safety is paramount in any aesthetic procedure. While Plinest is generally well-tolerated when administered by qualified practitioners, it is not suitable for everyone. You should avoid this treatment if you have any of the following conditions:
Pregnancy and Breastfeeding: The effects of polynucleotides have not been studied in pregnant or nursing women.
Known Allergies: Individuals with a known hypersensitivity to the product's components, including fish-derived polynucleotides, should not undergo treatment.
Active Skin Conditions: Do not treat areas with active infections (bacterial, viral, or fungal), inflammation, open wounds, or active skin diseases like eczema, psoriasis, or rosacea flare-ups.
Autoimmune Diseases: Patients with severe autoimmune disorders should consult their specialist, as the treatment stimulates the body's cellular response.
History of Keloid or Hypertrophic Scarring: Individuals prone to excessive scarring should exercise caution.
Bleeding Disorders or Anticoagulant Use: Those on blood-thinning medications (e.g., Warfarin, Aspirin) or with bleeding disorders have a higher risk of bruising and bleeding at the injection sites.
Recent Aggressive Skin Treatments: A suitable waiting period is necessary after treatments like deep chemical peels, laser resurfacing, or microneedling in the same area.
Always disclose your full medical history to your practitioner during the consultation to ensure Plinest is a safe and appropriate choice for you.
Plinest Compared to Other Aesthetic Injectables
The world of aesthetic injectables is vast, with each product offering unique benefits. Understanding how Plinest fits into this landscape is key to choosing the right treatment for your skin goals. Plinest is a biostimulator, meaning it works by triggering your skin's natural regenerative processes rather than simply filling or hydrating. Here’s a detailed comparison with other popular treatments.
Plinest vs. Rejuran Healer: Understanding the Differences
Plinest and Rejuran are often compared as they both belong to the polynucleotide (PN) family. While they share the same core ingredient derived from salmon DNA, they have distinct formulations and characteristics developed by different pharmaceutical companies—Mastelli in Italy (Plinest) and PharmaResearch in South Korea (Rejuran).
Plinest vs. Profhilo: Bioremodelling vs. Biostimulation
This comparison is between two different types of regenerative injectables. Plinest is a polynucleotide biostimulator, while Profhilo is a hyaluronic acid-based bioremodelling agent. They work through different pathways to achieve skin revitalisation.
Plinest vs. Traditional Dermal Fillers
Plinest and dermal fillers serve fundamentally different purposes. Fillers add volume and structure, while Plinest improves the skin's intrinsic quality and health without adding volume.
Plinest vs. Skin Boosters
Both Plinest and skin boosters aim to improve overall skin quality, but they achieve this through different primary ingredients and mechanisms. The choice between them often depends on whether your main concern is hydration or cellular-level repair.
Safety Profile and Potential Side Effects
Plinest is renowned for its high safety profile, rooted in its use of highly purified, biocompatible polynucleotides (PDRN) derived from Italian trout. As a biostimulator, it works in harmony with your body's natural processes. However, like any injectable aesthetic procedure, it's important to be aware of potential side effects and the measures in place to ensure a safe experience.
Common and Expected Side Effects
The most common side effects associated with Plinest are mild, temporary, and directly related to the injection process itself. These reactions typically subside on their own within a few hours to a couple of days post-treatment.
Rare Complications and How to Minimize Risks
While serious complications are uncommon when performed by qualified practitioners, they are possible. The risk is significantly reduced by choosing a certified professional and adhering to all pre- and post-care guidelines. Potential rare complications include:
Infection: Any procedure that breaks the skin barrier carries a small risk of infection. This is minimized by using sterile techniques in a clinical setting.
Allergic Reaction: As Plinest is highly purified, allergic reactions are uncommon. However, you should always disclose any known allergies, particularly to fish products, during your consultation.
Prolonged Swelling or Redness: In rare cases, inflammation may last longer than expected.
Nodule Formation (Granuloma): This is a very rare inflammatory reaction where the body forms a small, persistent lump around the injected material.
How to Minimize Risks:
Full Disclosure: Be completely transparent with your practitioner about your medical history,
current medications (especially blood thinners like aspirin or ibuprofen), and any allergies.
Follow Instructions: Strictly follow the pre-treatment and post-treatment care advice provided by your clinic. This often includes avoiding alcohol, strenuous exercise, and excessive heat for a short period.
Verify the Product: Ensure your practitioner is using authentic, HSA-approved Plinest from Mastelli Aesthetics.
Choose an Expert: The single most important factor in minimizing risk is the skill and experience of your injector.
The Importance of Choosing a Qualified Practitioner
The safety and success of your Plinest treatment are fundamentally dependent on the person administering it. A qualified practitioner is not just someone who can perform an injection; they are a medical professional with a deep understanding of facial anatomy, skin physiology, and sterile protocols.
What to Look For in a Practitioner:
Credentials: Your practitioner should be a licensed and insured doctor, doctor, or aesthetic nurse with specific training in injectable treatments.
Experience with Polynucleotides: Ask about their specific experience with biostimulators like Plinest. An experienced injector will know the correct depth, dosage, and technique for different areas of the face and body.
Thorough Consultation: A professional will conduct a comprehensive skin assessment, discuss your goals, explain the procedure in detail, and manage your expectations.
Clinical Environment: The treatment should be performed in a clean, hygienic medical setting to prevent infection.
Portfolio and Reviews: Ask to see before-and-after photos of their own patients and look for genuine patient reviews. A confident practitioner will be happy to share their results.
Treatment Areas Results and Longevity
Plinest is a versatile biostimulator valued for its ability to regenerate the skin from within. Its application is not limited to one area, and its results may be progressive and potentially long-lasting. Understanding where it can be used and the expected timeline for results is key to a successful treatment journey.
Popular Treatment Areas Face Neck and Décolletage
Plinest is highly effective for rejuvenating areas that show the most prominent signs of aging and environmental damage. Its primary function is to improve overall skin quality, texture, and elasticity rather than simply adding volume.
Full Face: Used across the face, Plinest addresses concerns like fine lines, poor texture, enlarged pores, and mild skin laxity. It restores a healthy, youthful canvas by promoting deep dermal regeneration.
Neck: This area often betrays age with horizontal lines ("tech neck") and crepey skin. Plinest helps to thicken and firm the delicate neck skin, softening lines and improving its overall appearance.
Décolletage: The chest area is frequently exposed to the sun, leading to photoaging, redness, and fine wrinkles. Plinest works to repair this sun damage, smooth the skin, and restore a more even, radiant tone.
Treating Difficult Areas Like Under the Eyes and Hands
Some of the most impressive results from Plinest are seen in delicate, hard-to-treat areas where traditional fillers may not be suitable.
Under the Eyes (Periorbital Area): Plinest may be considered for treating thin, crepey skin and fine lines around the eyes. By stimulating collagen, it helps to thicken the skin, which can reduce the appearance of dark circles caused by visible underlying blood vessels. It may offer natural-looking improvement with minimal risk of puffiness or the Tyndall effect.
Hands: The backs of the hands lose volume and skin quality over time, making tendons and veins more prominent. Plinest rejuvenates the skin on the hands, improving its thickness and elasticity for a smoother, more youthful look.
How Many Sessions Are Needed for Optimal Results
Plinest is not a single-session treatment. Achieving the best outcome requires a structured protocol designed to build and maintain regenerative momentum in the skin. While the exact plan is tailored to your specific skin condition and goals, a typical course of treatment follows a clear pattern.
When You Can Expect to See Results
As a biostimulator, Plinest delivers gradual and progressive results that look entirely natural. The timeline for visible changes reflects the body's cellular regeneration cycle. Patience is rewarded with authentic and lasting improvements.
How Long Do the Effects of Plinest Last
The regenerative effects of a full Plinest treatment course are long-lasting because the treatment stimulates your body to produce its own new, healthy tissue. The newly formed collagen and elastin fibers provide a durable structural improvement to the skin.
Typically, The visible benefits of Plinest may last for 6 to 12 months, though individual results vary.
The natural aging process continues, so a single maintenance session every 6 to 9 months is highly recommended to sustain the peak results. Longevity is also influenced by individual factors such as age, lifestyle, diet, and adherence to a good skincare routine, particularly consistent sun protection.
Understanding the Cost of Plinest
Investing in your skin's health is a significant decision, and understanding the financial aspect is a crucial part of the process. The cost of Plinest treatments can vary widely based on several key factors. This section breaks down the pricing structure to help you make an informed decision.
Factors That Determine the Price of Treatment
A single, fixed price for Plinest does not exist. The final cost you are quoted will be a combination of multiple variables unique to your treatment plan and provider. Key factors include:
Practitioner's Expertise: The skill, experience, and reputation of your injector play a major role. A board-certified doctor or a leading aesthetic doctor with specialized training in biostimulators will command a higher fee than a less experienced practitioner. This premium reflects a higher standard of safety and quality of results.
Geographic Location: Clinic overheads and market rates differ significantly from one city to another. Treatments in major metropolitan areas like London or New York will generally be more expensive than in smaller towns.
Treatment Area(s): The cost is directly related to the size and number of areas being treated. A targeted treatment for the under-eye area will cost less than a comprehensive plan for the full face, neck, and décolletage, which requires more product and clinical time.
Amount of Product Used: Plinest is supplied in pre-filled syringes. The total number of syringes needed to adequately cover the treatment zone and achieve your desired goals will directly influence the final price.
Number of Sessions: Optimal results with Plinest are achieved through a course of treatments, typically 2-4 sessions. While some clinics price per session, many offer package deals for a full course, which can lower the overall cost.
Is Plinest a Cost-Effective Skin Investment
When evaluating the cost, it's helpful to view Plinest as a long-term investment in your skin's foundational health rather than a temporary cosmetic fix. Here’s how to assess its value:
Regenerative vs. Symptomatic Treatment: Unlike traditional fillers that primarily add volume to mask wrinkles, Plinest is a biostimulator that works at a cellular level. It encourages your body to produce its own collagen and elastin, leading to genuine, long-lasting improvements in skin quality, firmness, and texture. This regenerative approach addresses the root cause of aging.
Preventative Benefits: By improving skin resilience and health from within, regular Pline
equipped to resist future signs of aging, potentially reducing the need for more invasive and costly corrective procedures down the line.
Natural and Lasting Results: For individuals who prioritize natural-looking results, Plinest is an excellent choice. The investment yields a refreshed, radiant, and healthier appearance, not an altered or "done" look. The effects are gradual and sustained, reflecting true skin rejuvenation.
Beyond Topical Skincare: While the upfront cost of Plinest is higher than over-the-counter creams and serums, its efficacy is on a completely different level. Polynucleotides deliver active ingredients directly to the dermis, achieving cellular regeneration that topical products cannot.
Ultimately, for those seeking to fundamentally improve their skin's health and achieve a durable, natural anti-aging effect, Plinest represents a highly cost-effective and strategic investment in their long-term appearance and confidence.
Frequently Asked Questions
Is the Plinest Treatment Painful?
Patient comfort is a priority during any aesthetic procedure. Before the Plinest treatment begins, a topical numbing cream is typically applied to the target area to minimize any discomfort. The injections are administered using very fine needles. Most patients report feeling only a slight pinprick sensation during the injection process. The procedure is generally well-tolerated, with minimal pain involved.
Can Plinest Be Combined With Other Aesthetic Treatments?
Yes, Plinest is an excellent combination treatment. Its regenerative properties can complement and enhance the results of other aesthetic procedures. It works synergistically with treatments such as:
Dermal Fillers: While fillers add volume, Plinest improves the skin quality and structure around them.
Neurotoxins (e.g., Botox): Neurotoxins relax muscles to reduce dynamic wrinkles, while Plinest repairs the static lines and improves overall skin health.
Laser Treatments & Microneedling: Plinest can be used to prepare the skin before these procedures or to accelerate healing and boost collagen production afterward.
Profhilo: While both improve skin quality, Profhilo focuses on deep hydration and bioremodelling with hyaluronic acid, whereas Plinest focuses on cellular regeneration via polynucleotides. They can be used together in a comprehensive anti-aging plan.
Always consult with your practitioner to create a safe and effective treatment schedule that staggers procedures appropriately.
Is Plinest Made From Salmon DNA?
This is a common misconception, often due to the popularity of other polynucleotide products. Plinest is uniquely derived from the DNA of Italian Trout Fish, not salmon. The polynucleotides are sourced and manufactured by Mastelli, an Italian pharmaceutical company, using their proprietary High Purification Technology (HPT™). This process ensures the DNA is thoroughly purified, removing all other proteins and immunogenic components, resulting in a highly safe, biocompatible product that does not trigger allergic reactions.
How is Plinest Different from Plinest Fast?
Plinest and Plinest Fast are two distinct products within the Plinest range, designed for different purposes and treatment areas. The primary differences lie in their polynucleotide concentration and viscosity, which dictates their ideal use.
Summary
Plinest represents a significant advancement in aesthetic medicine, moving beyond simple volumization to focus on true skin regeneration. As a polynucleotide-based biostimulator, it works at a cellular level to repair, rejuvenate, and restore the skin's natural health and vitality.
By stimulating the body's own production of collagen and elastin, Plinest offers a gradual, natural-looking improvement in skin quality, texture, and resilience. It is an excellent option for individuals seeking to address the root causes of skin aging and damage rather than merely masking the symptoms.
Below is a quick-reference table summarizing the essential aspects of Plinest treatment.
Ultimately, choosing Plinest is an investment in your skin's long-term health. Its ability to fundamentally improve the skin's foundational structure makes it a powerful tool against the aging process. A thorough consultation with a qualified and experienced practitioner is essential to confirm your suitability and develop a personalized treatment plan that aligns with your aesthetic goals.
Note: This article is for educational purposes only and does not constitute medical advice. Individual treatment plans should be developed in consultation with qualified healthcare professionals. Treatment outcomes vary from person to person, and no guarantee of results is intended or implied. All professional treatments mentioned should be performed by licensed medical practitioners in Singapore, using HSA-approved or otherwise MOH-approved products, devices, and techniques, as applicable.
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