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Doxycycline for Acne: An Effective Treatment Option

Updated: Mar 11

Acne is a common skin condition that affects millions of people worldwide. It can cause significant emotional distress and impact an individual's quality of life. One of the treatment options that has shown promise is doxycycline, an antibiotic that's been used for decades to treat various bacterial infections, including acne.


Various medication and antibiotics laid out on a surface

What is Doxycycline?

Doxycycline is an antibiotic that belongs to the tetracycline class of drugs. It's used to treat a variety of bacterial infections, including those that cause acne. It works by inhibiting the growth and spread of bacteria, thereby helping to reduce inflammation and clear up the skin.

How Does Doxycycline Treat Acne?

Doxycycline treats acne by targeting the bacteria that contribute to the development of acne. It's particularly effective against Propionibacterium acnes, the bacteria most commonly associated with acne. In addition to its antibacterial properties, doxycycline also has anti-inflammatory effects, which can help to reduce the redness and swelling associated with acne.

Efficacy and Safety of Doxycycline for Acne

Numerous studies have demonstrated the efficacy of doxycycline in treating acne. Most prominently, a study published in the Journal of the American Academy of Dermatology found that doxycycline significantly reduced acne lesions in patients after 12 weeks of treatment. As for safety, doxycycline is generally well-tolerated, but like all medications, it can cause side effects. The most common ones include sun sensitivity, nausea, and diarrhoea.

The Role of Doxycycline in Combination Therapies

Doxycycline is often used in combination with other acne treatments for enhanced effectiveness. For example, a study published in the Journal of Drugs in Dermatology found that a combination of doxycycline and trifarotene, a topical retinoid, was more effective in reducing acne lesions than either treatment alone. However, combination therapies may also increase the risk of side effects, so it's important to discuss this with your healthcare provider.

Duration of Doxycycline Treatment

The recommended duration of doxycycline treatment for acne varies depending on the individual's response to treatment, but it's typically limited to three months. This is to prevent the development of antibiotic resistance, a serious global health concern. Antibiotic resistance occurs when bacteria evolve in response to the use of these medications and become resistant to their effects. This can make future bacterial infections more difficult to treat. If acne persists after this period, other treatment options may be considered.


Doxycycline is a promising treatment option for acne, with research supporting its efficacy and safety. However, as with any medication, it's important to use it under the guidance of a healthcare provider. If you're struggling with acne, talk to your healthcare provider about whether doxycycline could be a suitable treatment option for you.

Schedule a consultation today and start your acne recovery journey today.

This blog post was medically reviewed by Dr Summer Zhang.


1. Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Bhushan, R. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology


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