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Adapalene Treatment: Better Results for Acne

Updated: Mar 14

Acne is a common skin condition that affects millions worldwide. While there are numerous treatments available, a new approach has emerged that combines three potent ingredients for even better results. Let's dive into the science behind the efficacy of adapalene, especially when combined with other powerful acne-fighting agents.


A clinic professional arranging medication in a drawer

Understanding Adapalene

Adapalene is a type of retinoid, known for its efficacy in treating acne. It works by unclogging pores and reducing inflammation, making it a popular choice for many dermatologists.

The Triple-Combination Approach

Recent studies have explored the benefits of combining adapalene with other acne treatments. One such study, led by Dr. Linda Stein Gold, focused on a triple-combination approach, merging an antibiotic, antibacterial, and retinoid – Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel– for a comprehensive acne solution.

Key Findings from the Study

1. Superior Efficacy: The study found that over half of the participants (52.5%) achieved treatment success at week 12 when using the triple-combination gel, significantly outperforming other treatments.

2. Significant Reduction in Lesions: The combination treatment led to over 70% reductions in both inflammatory and non-inflammatory lesions, showcasing its potency.

3. Safety and Tolerability: The triple-combination gel was well-tolerated by participants, with most adverse events being mild to moderate. Common side effects included application-site pain and dryness.

The results from Dr. Gold's study suggest that a three-pronged approach to acne treatment can offer superior results compared to traditional methods. By targeting acne from multiple angles, this method can potentially improve patient compliance, reduce antibiotic resistance, and provide faster, more noticeable results.

Schedule a consultation today and start your acne recovery journey today.


Acne treatment has come a long way, and with the introduction of combination therapies like the one involving adapalene, there's hope for even better, faster results. If you or a loved one is struggling with persistent acne, it might be time to consider this triple-combination approach.

This blog post was medically reviewed by Dr Summer Zhang.


  1. A. Leung, B. Barankin, J. Lam, K. Leong, K. Hon. (2021). Dermatology: how to manage acne vulgaris

  2. A. Zaenglein, A. Pathy, B. Schlosser, A. Alikhan, H. Baldwin, D. Berson, W. Bowe, E. Graber, J. Harper, S. Kang, J. Keri, J. Leyden, R. Reynolds, N. Silverberg, L. Gold, M. Tollefson, J. Weiss, N. Dolan, A. Sagan, M. Stern, K. Boyer, R. Bhushan. (2016). Guidelines of care for the management of acne vulgaris


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